The Rcs phosphorelay system is essential for pathogenicity inErwinia amylovora
نویسندگان
چکیده
منابع مشابه
New Insights into the Non-orthodox Two Component Rcs Phosphorelay System
The Rcs phosphorelay system, a non-orthodox two-component regulatory system, integrates environmental signals, regulates gene expression, and alters the physiological behavior of members of the Enterobacteriaceae family of Gram-negative bacteria. Recent studies of Rcs system focused on protein interactions, functions, and the evolution of Rcs system components and its auxiliary regulatory prote...
متن کاملDefective lipoprotein sorting induces lolA expression through the Rcs stress response phosphorelay system.
The Escherichia coli LolA protein is a lipoprotein-specific chaperone that carries lipoproteins from the inner to the outer membrane. A dominant negative LolA mutant, LolA(I93C/F140C), in which both (93)Ile and (140)Phe are replaced by Cys, binds tightly to the lipoprotein-dedicated ABC transporter LolCDE complex on the inner membrane and therefore inhibits the detachment of outer membrane-spec...
متن کاملLrhA regulates rpoS translation in response to the Rcs phosphorelay system in Escherichia coli.
Regulation of the Escherichia coli stationary-phase sigma factor RpoS is complex and occurs at multiple levels in response to different environmental stresses. One protein that reduces RpoS levels is the transcription factor LrhA, a global regulator of flagellar synthesis. Here we clarify the mechanism of this repression and provide insight into the signaling pathways that feed into this regula...
متن کاملThe RcsCB His-Asp phosphorelay system is essential to overcome chlorpromazine-induced stress in Escherichia coli.
The RcsCB His-Asp phosphorelay system regulates the expression of several genes of Escherichia coli, but the molecular nature of the inducing signal is still unknown. We show here that treatment of an exponentially growing culture of E. coli with the cationic amphipathic compound chlorpromazine (CPZ) stimulates expression of a set of genes positively regulated by the RcsCB system. This inductio...
متن کاملThe Chemical Arsenal of Burkholderia pseudomallei Is Essential for Pathogenicity
Increasing evidence has shown that small-molecule chemistry in microbes (i.e., secondary metabolism) can modulate the microbe-host response in infection and pathogenicity. The bacterial disease melioidosis is conferred by the highly virulent, antibiotic-resistant pathogen Burkholderia pseudomallei (BP). Whereas some macromolecular structures have been shown to influence BP virulence (e.g., secr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Plant Pathology
سال: 2009
ISSN: 1464-6722,1364-3703
DOI: 10.1111/j.1364-3703.2008.00531.x